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discover that the blood moved��that was known to Aristotle and to Galen�察�

from   both   of   whom   I   have   given   quotations   which   indicate   clearly   that 

they    knew    of  its  movement��but       at  the  time   of  Harvey     not  a  single 

anatomist      had   escaped     from   the   domination      of  Galen's    views。    Both 

Servetus   and   Colombo   knew   of   the   pulmonary   circulation�察  �which   was 

described by the former in very accurate terms。 Cesalpinus�察�a great name 

in   anatomy      and   botany�察   �for  whom      is  claimed    the   discovery     of  the 

circulation�察  �only   expressed   the   accepted   doctrines   in   the   following   oft´ 

quoted phrase�此�

     ;We will now consider how the attraction of aliment and the process of 

nutrition takes place in plants�察�for in animals we see the aliment brought 

through the veins to the heart�察�as to a laboratory of innate heat�察�and�察�after 

receiving there its final perfection�察�distributed through the arteries to the 

body at large�察�by the agency of the spirits produced from this same aliment 

in the heart。;��30�А�There is nothing in this but Galen's view�察�and Cesalpinus 

believed�察  �as   did   all   his   contemporaries�察  �that   the   blood   was   distributed 

through the body by the vena cava and its branches for the nourishment of 

all its parts。��*�А�To those who have any doubts as to Harvey's position in 

this matter I would recommend the reading of the ;De Motu Cordis; itself�察�

then   the   various    passages   relating    to  the   circulation   from   Aristotle   to 

Vesalius。 Many of these can be found in the admirable works of Dalton�察�

Flourens�察 �Richet   and   Curtis。��31�А  �In   my  Harveian   Oration   for   1906��32�А  �I 

have dealt specially with the reception of the new views�察�and have shown 

how     long    it  was   before    the   reverence     for  Galen     allowed    of   their 

acceptance。 The University of Paris opposed the circulation of the blood 

for more than half a century after the appearance of the ;De Motu Cordis。; 

     ��30�А�De Plantis�察�Lib I�察�cap。 2。 

     ��*�А�Cesalpinus has also a definite statement of the circlewise process。 

Ed。 

     ��31�А  �J。   C。   Dalton   Doctrines   of   the   Circulation�察  �Philadelphia�察  �1884�察�



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Flourens Histoire de la decouverte de la circulation du sang�察�2d ed。�察�Paris�察�

1857�察�Charles Richet Harvey�察�la circulation du sang�察�Paris�察�1879�察�John G。 

Curtis Harvey's views on the use of Circulation�察�etc。�察�New York�察�1916。 

     ��32�А   �Osler   An    Alabama     Student    and   Other    Biographical     Essays�察�

Oxford�察�1908�察�p。 295。 

       To summarizeuntil the   seventeenth   century there   were believed  to 

be two closed systems in the circulation�察。�1�� the natural�察�containing venous 

blood�察�had its origin in the liver from which�察�as from a fountain�察�the blood 

continually ebbed and flowed for the nourishment of the body�察。�2�� the vital�察�

containing another blood and the spirits�察�ebbed and flowed from the heart�察�

distributing heat and life to all parts。 Like a bellows the lungs fanned and 

cooled this vital blood。 Here and there we find glimmering conceptions of 

a   communication        between     these  systems�察   �but   practically    all  teachers 

believed that the only one of importance was through small pores in the 

wall separating the two sides of the heart。 Observationmerely looking at 

and   thinking   about   thingshad   done   all   that   was   possible�察  �and   further 

progress had to await the introduction of a new method�察�viz。�察�experiment。 

Galen�察�it is true�察�had used this means to show that the arteries of the body 

contained blood and not air。 The day had come when men were no longer 

content with accurate description and with finely spun theories and dreams。 

It   was    reserved    for  the   immortal     Harvey     to  put   into   practice    the 

experimental      method     by   which   he   demonstrated      conclusively    that   the 

blood moved in a circle。 The ;De Motu Cordis; marks the final break of 

the modern spirit with the old traditions。 It took long for men to realize the 

value of this ;inventum mirabile; used so effectively by the Alexandrians´ 

´by Galenindeed�察�its full value has only been appreciated within the past 

century。 Let me quote a paragraph from my Harveian Oration。��33�А �To the 

age of the hearer�察�in which men had heard and heard only�察�had succeeded 

the age of the eye in which men had seen and had been content only to see。 

But   at   last   came   the   age   of   the   hand   the   thinking�察  �devising�察  �planning 

hand�察�the hand as an instrument of the mind�察�now re´introduced into the 

world in a modest little monograph from which we may date the beginning 

of experimental medicine。; 

     ��33�А�Osler�此�An Alabama Student�察�etc。�察�pp。 329´330。 



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       Harvey   caught   the   experimental   spirit   in   Italy�察  �with   brain�察  �eye   and 

hand as his only aids�察�but now an era opened in which medicine was to 

derive     an   enormous      impetus     from     the   discovery     of   instruments     of 

precision。   ;The   new   period   in   the   development   of   the   natural   sciences�察�

which reached its height in the work of such men as Galileo�察�Gilbert and 

Kepler�察    �is  chiefly    characterized      by   the   invention    of   very    important 

instruments for   aiding and   intensifying the perceptions of the senses�察 �by 

means   of   which   was   gained   a   much   deeper   insight   into   the   phenomena 

than    had   hitherto    been   possible。    Such    instruments     as  the   earlier  ages 

possessed were little more than primitive hand´made tools。 Now we find a 

considerable       number      of   scientifically    made     instruments      deliberately 

planned for purposes of special research�察�and as it were�察�on the threshold 

of the period stand two of the most important�察�the compound microscope 

and   the   telescope。   The   former   was   invented   about   1590   and   the   latter 

about 1608。;��34�А�It was a fellow professor of the great genius Galileo who 

attempted to put into practice the experimental science of his friend。 With 

Sanctorius began the studies of temperature�察�respiration and the physics of 

the circulation。 The memory of this great investigator has not been helped 

by   the   English   edition   of   his   ;De   Statica   Medicina�察─  �not   his   best   work�察�

with a frontispiece showing the author in his dietetic balance。 Full justice 

has been done to him by Dr。 Weir Mitchell in an address as president of 

the   Congress   of   Physicians   and   Surgeons�察  �1891。��35�А  �Sanctorius   worked 

with    a   pulsilogue    devised     for  him    by   Galileo�察  �with    which    he   made 

observations on the pulse。 He is said to have been the first to put in use the 

clinical thermometer。 His experiments on insensible perspiration mark him 

as one of the first modern physiologists。 

     ��34�А  �Dannemann�此  �Die   Naturwissenschaften   in   ihrer   Entwickelung。。。�察�

Vol。 II�察�p。 7�察�Leipzig�察�1911。 

     ��35�А�See Transactions Congress Physicians and Surgeons�察�1891�察�New 

Haven�察�1892�察�II�察�159´181。 

       But neither Sanctorius nor Harvey had the immediate influence upon 

their   contemporaries   which   the   novel   and   stimulating   character   of   their 

work justified。 Harvey's great contemporary�察�Bacon�察�although he lost his 

life   in   making   a   cold   storage   experiment�察  �did   not   really   appreciate   the 



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enormous       importance     of  experimental      science。   He    looked    very   coldly 

upon     Harvey's     work。    It  was   a  philosopher      of  another    kidney�察   �Rene 

Descartes�察�who did more than anyone else to help men to realize the value 

of   the   better   way   which   Harvey   had   pointed   out。  That   the   beginning   of 

wisdom was in doubt�察�not in authority�察�was a novel doctrine in the world�察�

but Descartes was no armchair philosopher�察�and his strong advocacy and 

practice of experimentation had a profound influence in directing men to 

;la nouvelle methode。; He brought the human body�察�the earthly machine�察�

as he calls it�察�into the sphere of mechanics and physics�察�and he wrote the 

first   text´book    of  physiology�察     �De   l'Homme。;      Locke�察   �too�察  �became     the 

spokesman   of   the   new   questioning   spirit�察      �and   before   the   close   of   the 

seventeenth century�察�experimental research became all the mode。 Richard 

Lower�察  �Hooke   and   Hales   were   probably   more   influence
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